Lucy, The Daughter of the Devil

Created by Loren Bouchard, one of the two guys behind Home Movies, Lucy is one of the first computer-animated shows on Adult Swim and has a style of humor that fits in perfectly with most of that lineup. The premise is fairly outlandish, with special forces from the Vatican chasing after a relatively normal girl who happens to date the Messiah and be the daughter of the Devil, as the show's title would indicate. Despite the plot, the meat of the humor comes from the natural dialogue between the characters. H. Jon Benjamin frequently makes guest appearances on other Adult Swim shows, and since his days as the coach on Home Movies, is one of the funniest voice actors they have. Whether following a script or just improvising, he's always good, although I wouldn't say his work on this show is really his best.

As is the trend now, Lucy has a strain of continuity running through the whole season, so even if a particular episode has an isolated plot you can still see them moving forward towards something. It builds to a conflict with all the main characters, someone running for office with the Devil's help, and a gigantic monster. The season wasn't very long, but it quickly developed into a really enjoyable show. Lucy isn't quite the main character since she doesn't have the most screen time, but everything sort of revolves around her and she's pretty likable. Jesus and the secret clergy are probably my favorite cast members, and I'm hoping they do pick up the show for a second season.

UPDATE: They didn't.